“This essay will discuss nine topics, that, in my view, are the main challenges for a pluralist-heterodox agenda for virus eco²nomics. They could be an orientation for a seminar, and I offer them as if they were a first draft of a syllabus, along with objectives/questions. At the end of each topic, research questions are formulated. The underlying assumption of this paper is that COVID-19 is a challenge for humanity like the Spanish flu, the most dangerous influenza until recently.” (H. Peukert)